Obama wins Fla., topping Romney in final tally

President Barack Obama was declared the winner of Florida's 29 electoral votes Saturday, ending a four-day count with a razor-thin margin that narrowly avoided an automatic recount that would have brought back memories of 2000.

No matter the outcome, Obama had already clinched re-election and now has 332 electoral votes to Romney's 206.

The Florida Secretary of State's Office said that with almost 100 percent of the vote counted, Obama led Republican challenger Mitt Romney 50 percent to 49.1 percent, a difference of about 74,000 votes. That was over the half-percent margin where a computer recount would have been automatically ordered unless Romney had waived it.

There is a Nov. 16 deadline for overseas and military ballots, but under Florida law, recounts are based on Saturday's results. Only a handful of overseas and military ballots are believed to remain outstanding.

It's normal for election supervisors in Florida and other states to spend days after any election counting absentee, provisional, military and overseas ballots. Usually, though, the election has already been called on election night or soon after because the winner's margin is beyond reach.

But on election night this year, it was difficult for officials — and the media — to call the presidential race here, in part because the margin was so close and the voting stretched into the evening.

In Miami-Dade, for instance, so many people were in line at 7 p.m. in certain precincts that some people didn't vote until after midnight.

The hours-long wait at the polls in some areas, a lengthy ballot and the fact that Gov. Rick Scott refused to extend early voting hours has led some to criticize Florida's voting process. Some officials have vowed to investigate why there were problems at the polls and how that led to a lengthy vote count.

If there had been a recount, it would not be as difficult as the lengthy one in 2000. The state no longer uses punch-card ballots, which became known for their hanging chads. All 67 counties now use optical scan ballots where voters mark their selections manually.

Republican George W. Bush won the 2000 contest after the Supreme Court declared him the winner over Democrat Al Gore by a scant 537 votes.

The win gave Obama victories in eight of the nine swing states, losing only North Carolina. In addition to Florida, he won Ohio, Iowa, New Hampshire, Wisconsin, Virginia, Colorado and Nevada.

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Philip Roth Is Retiring; Amazon Glitch Disables Buy Buttons

Today in books and publishing: Philip Roth confirms his retirement; Amazon‘s mysteriously vanishing buy buttons; Kobo expands to Italy, Kindle considers China; cities in literature.

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Philip Roth wraps it up. One of America’s most celebrated living novelists has been hinting at retirement for a while now. But he didn’t choose to make a big announcement in a prominent stateside literary organ like The New York Review of Books. He chose instead to let it out in interviews with the foreign press over recent weeks. Last month he told Nelly Kaprièlian of French magazine Les Inrockuptibles that he hasn’t written new material in three years, and doesn’t plan to write any new novels. “To tell you the truth, I’m done,” he said frankly, “Nemesis will be my last book … Enough is enough! I no longer feel this fanaticism to write that I have experienced in my life.” He said the same thing in an interview with Italian magazine La Repubblica earlier this month. His publisher Houghton Mifflin confirmed that Roth is entering retirement. It looks the 74-year-old writer will have plenty of time to go over his life story and thoughts on literature with his new biographer, Blake Bailey. [Salon]

RELATED: How to Game Amazon Prime; Random House Consolidates in the Spanish Market

Where did Amazon‘s buy buttons go? Late last night, customers looking to replenish their Kindles with fresh e-books were probably quite frustrated. No matter how hard anyone clicked, there was no way to purchase e-books from Penguin, Random House, Macmillan, Simon & Schuster, Hachette, and HarperCollins through Amazon. A company spokesperson later confirmed that it was just a technical slip-up, and buy buttons were quickly restored. But given Amazon’s propensity to punish publishers that don’t bend to its will with disabled buy buttons, this brief black-out set off a minor panic in publishing land. Why were only Big Six publishers affected? Did it have anything to do with the ongoing agency pricing legal battles or the Penguin Random House merger? Though it seems to have been nothing more serious than a technical goof, it’s a stark reminder that Amazon has the ability—as well as the leverage—to shut down publishers’ most important connection with consumers at the click of a mouse. [New York Observer]

RELATED: Chart: The Rapid Gains of the E-book

E-reading takes a global turn. E-books may be taking firm holds in the U.S., but they have a long way to go before they became the global format of choice for readers. Italy may be going in an increasingly digital direction soon, with the country’s largest bookseller Mondadori Group partnering with Kobo to stock Touch e-readers in its hundreds of stores. 34,000 e-books will be available for Italian readers. China is another largely untapped market, one that Amazon is eyeing enviously. ZDNet’s Liau Yun Qing reports that Kindles may become available there as early as this month. “If Amazon brings its e-reader to China, it will face competition from Chinese e-commerce player Dangdang which launched its e-reader in July at a retail price of 599 yuan (US$ 79),” she writes. “In comparison, the cheapest Kindle Paperwhite e-reader, which includes “Special Offers”, retails at US$ 119 in the United States.” [ZDNet]

RELATED: New Batman Comic Postponed; Books Banned in China Thrive in Hong Kong

Cities in literature. Mark Binelli’s new book Detroit City Is the Place to Be is all about the Motor City—its ascent during America’s industrial golden age, and its struggle to redefine itself. Given his obsession with the urban, Publishers Weekly decided to tap Binelli for a list of his favorite books that take specific cities as a central theme. It’s more interesting than most lists on this subject might have been. For instance, he shines a light on Joan Didion not for her classic takes on San Francisco or New York, but for her book Miami. And his favorite books to take on New York—Ben Katchor’s The Jew of New York and Joseph Mitchell’s Up in the Old Hotel—are refreshing inclusions. His favorite book about Detroit, Elmore Leonard’s City Primeval, is also a bit surprising. [Publishers Weekly]

Gadgets News Headlines – Yahoo! News

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AP source: Justin Bieber and Selena Gomez break up

NEW YORK (AP) — A source confirms to The Associated Press that Justin Bieber is no longer Selena Gomez's "Boyfriend."

The source is not authorized to discuss the split with the press and spoke on condition of anonymity.

The breakup apparently happened last week. Distance and their busy schedules were cited as factors.

Eighteen-year-old Bieber is touring to promote his latest album, "Believe," which contains the hit "Boyfriend." Twenty-year-old Gomez is filming a "Wizards of Waverly Place" reunion for the Disney Channel.

The pair made their relationship public in February 2011.

E! News was the first to report the split.

Bieber seems to be doing OK, at least publicly. On the red carpet of Wednesday's Victoria's Secret fashion show he said, "I'd rather be here than anywhere in the world."

___

Online:

http://www.justinbiebermusic.com/

http://www.selenagomez.com/

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The New Old Age Blog: The Emotional Aftermath of Hurricane Sandy

Let’s talk about the emotional aftermath of the storm that left tens of thousands of older people on the East Coast without power, bunkered down in their homes, chilled to the bone and out of touch with the outside world.

Let’s name the feelings they may have experienced. Fear. Despair. Hopelessness. Anxiety. Panic.

Linda Leest and her staff at Services Now for Adult Persons in Queens heard this in the voices of the older people they had been calling every day, people who were homebound and at risk because of medical conditions that compromise their physical functioning.

“They’re afraid of being alone,” she said in a telephone interview a few days after the storm. “They’re worried that if anything happens to them, no one is going to know. They feel that they’ve lost their connection with the world.”

What do we know about how older adults fare, emotionally, in a disaster like that devastating storm, which destroyed homes and businesses and isolated older adults in darkened apartment buildings, walk-ups and houses?

Most do well — emotional resilience is an underappreciated characteristic of older age — but those who are dependent on others, with pre-existing physical and mental disabilities, are especially vulnerable.

Most will recover from the disorienting sense that their world has been turned upside down within a few weeks or months. But some will be thrown into a tailspin and will require professional help. The sooner that help is received, the more likely it is to prevent a significant deterioration in their health.

The best overview comes from a November 2008 position paper from the American Association for Geriatric Psychiatry that reviewed the effects of Hurricane Katrina and other disasters. After Katrina, “the elderly had the highest mortality rates, health decline and suicide rates of any subgroup,” that document notes. “High rates of psychosomatic problems were seen, with worsening health problems and increased mortality and disability.”

This is an important point: Emotional trauma in older adults often is hard to detect, and looks different from what occurs in younger people. Instead of acknowledging anxiety or depression, for instance, older people may complain of having a headache, a bad stomachache or some other physical ailment.

“This age group doesn’t generally feel comfortable talking about their feelings; likely, they’ll mask those emotions or minimize what they’re experiencing,” said Dr. Mark Nathanson, a geriatric psychiatrist at Columbia University Medical Center.

Signs that caregivers should watch out for include greater-than-usual confusion in an older relative, a decline in overall functioning and a disregard for “self care such as bathing, eating, dressing properly and taking medication,” Dr. Nathanson said.

As an example, he mentioned an older man who had “been sitting in a cold house for days and decided to stop taking his water pill because he felt it was just too much trouble.” Being distraught or distracted and forgetting or neglecting to take pills for chronic conditions like diabetes or heart disease can have immediate harmful effects.

Especially at risk of emotional disturbances are older adults who are frail and advanced in age, those who have cognitive impairments like Alzheimer’s disease, those with serious mental illnesses like schizophrenia or major depression, and those with chronic medical conditions or otherwise in poor physical health, according to the geriatric psychiatry association’s position paper.

A common thread in all of the above is the depletion of physical and emotional reserves, which impairs an older person’s ability to adapt to adverse circumstances.

“In geriatrics, we have this idea of the ‘geriatric cascade’ that refers to how a seemingly minor thing can set in motion a functional, cognitive and psychological downward spiral” in vulnerable older adults, said Dr. Mark Lachs, chief of the division of geriatrics at Weill Cornell Medical College. “Well, the storm was a major thing — a very large disequilibrating event — and its impact is an enormous concern.”

Of special concern are older people who may be in the early stages of Alzheimer’s disease or other types of dementia who are living alone. For this group, the maintenance of ordinary routines and the sense of a dependable structure in their lives is particularly important, and “a situation like Sandy, which causes so much disruption, can be a tipping point,” Dr. Lachs said.

Also of concern are older people who may have experienced trauma in the past, and who may suffer a reignition of post-traumatic stress symptoms because of the disaster.

Most painful of all, for many older adults, is the sense of profound isolation that can descend on those without working phones, electricity or relatives who can come by to help.

“That isolation, I can’t tell you how disorienting that can be,” said Bobbie Sackman, director of public policy for the Council of Senior Centers and Services of New York City. “They’re scared, but they won’t tell you because they’re too proud and ashamed to ask for help.”

The best remedy, in the short run, is the human touch.

“Now is the time for people to reach out to their neighbors in high-rises or in areas where seniors are clustered, to knock on doors and ask people how they are doing,” said Dr. Gary Kennedy, director of the division of geriatric psychiatry at Montefiore Medical Center in the Bronx.

Don’t make it a one-time thing; let the older person know you’ll call or come by again, and set up a specific time so “there’s something for them to look forward to,” Dr. Kennedy said. So-called naturally occurring retirement communities with large concentrations of older people should be organizing from within to contact residents who may not be connected with social services and find out how they’re doing, he recommended.

In conversations with older adults, offer reassurance and ask open-ended questions like “Are you low on pills?” or “Can I run out and get you something?” rather than trying to get them to open up, experts recommended. Focusing on problem-solving can make people feel that their lives are being put back in order and provide comfort.

Although short-term psychotherapy has positive outcomes for older adults who’ve undergone a disaster, it’s often hard to convince a senior to seek out mental health services because of the perceived stigma associated with psychological conditions. Don’t let that deter you: Keep trying to connect them with services that can be of help.

Be mindful of worrisome signs like unusual listlessness, apathy, unresponsiveness, agitation or confusion. These may signal that an older adult has developed delirium, which can be extremely dangerous if not addressed quickly, Dr. Nathanson said. If you suspect that’s the case, call 911 or make sure you take the person to the nearest hospital emergency room.

This is a safe place to talk about all kinds of issues affecting older adults. Would you be willing to share what kinds of mental health issues you or family members are dealing with since the storm so readers can learn from one another?

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Indoor trampoline parks spring up throughout Southland

Indoor trampoline parks are springing into action throughout Southern California, along with leaping games of dodge ball, highflying basketball and rigorous calisthenics.

Just ask Akory Coates, who lived out his basketball dreams for an hour recently at a Sky Zone trampoline park in Torrance. He jumped, he twirled in the air, his fingertips grazed the rim and he made four baskets. Not an easy feat for a 9-year-old, but a series of trampolines beneath his feet gave him all the lift he needed.

"Hey, Dad, look at me," Akory said as he went up for a basket and made it. His father took the fourth-grader at Major Lynn Mokler Elementary in Paramount and friends to the park for the boy's birthday. Across the warehouse a SkyRobics exercise class was underway, and a small group of parents watched their kids tumble.

The indoor trampoline business is booming, with dozens of parks open or in the works across America. "Since early to mid-2010 the whole industry has exploded," said Jeff Platt, chief executive of Sky Zone Indoor Trampoline Park, a Los Angeles company that opened its first location in Las Vegas in 2004. "People started feeling a little bit better about the economy and were looking for something new to do."

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At a time when the Southland economy is still struggling, experts say trampoline parks appeal to people of all ages eager for a relatively inexpensive activity and exercise. An hour at these parks typically ranges from $10 to $15. Many of them offer birthday parties, aerobics classes, corporate events and dodge ball games. There are also foam pits for people to jump into, and there are pizzas and hot dogs at the snack bar.

"We've seen them take off," said Dennis Speigel, president of International Theme Park Services Inc., an industry consultant. "They're not taking off like the space shuttle, but we are seeing a reemergence of them."

Speigel said trampoline parks came into existence in the late '50s and early '60s but fell out of favor because of liability. Today's trampoline parks, he said, are attractive to teens and preteens who like extreme sports such as skateboarding, BMX and snowboarding.

Sky Zone has opened 27 parks — three company owned and 24 franchises. Four are in Southern California, in Torrance, Anaheim, Corona-Riverside and Chula Vista near San Diego.

At least four other companies have opened trampoline parks across the country. Sky High Sports has 15 outlets including ones in Valencia, Woodland Hills, San Diego, Costa Mesa, Ontario and Camarillo.

Jump Street has nine locations combined in Arizona, Colorado and Texas, with plans to open two more. Xtreme Trampolines has two locations in the Chicago suburbs. Rebounderz has one outlet in Florida.

Jerry Raymond, CEO of Sky High Sports and a founding member of the International Assn. of Trampoline Parks, estimates there are just over 100 facilities in the United States and expects that number to grow. Most of the parks are franchises; none of the companies involved released profitability information.

Franchises for bigger companies such as Sky High and Sky Zone typically cost more than $1 million each to open, including insurance coverage, fees and facility costs.

Platt, Sky Zone's CEO, said the key to a successful trampoline franchise is introducing new activities.

After Sky Zone's revenue started to decline in 2009, five years after opening, it introduced dodge ball, then workout classes and basketball hoops. The moves paid off. Last year Sky Zone posted about $16 million in revenue and it's projecting $70 million for 2013.

Park operators say they make special effort to keep trampoline parks as safe as possible, but they acknowledge that injuries and liability are always a concern. "Injuries aren't something that we'll ever be able to eliminate, but we can try," Platt said.

As trampoline parks continue to multiply so will injuries, said Seattle lawyer Sim Osborn, who has represented clients who have injured themselves at trampoline parks. He said bodies can't absorb the impact of accidentally landing on the pads that border the trampolines, the facilities can get overcrowded and employees can't always supervise jumpers.

"Frankly, the way they're designed and built, you cannot make them safe," he said.

Although trampoline injury rates have decreased every year since 2004, the U.S. Consumer Product Safety Commission found there were almost 98,000 injuries in 2009, the latest year data were available.

In September, the American Academy of Pediatrics issued a warning about possible safety hazards involving trampoline use. The group also recommended that operators inform participants of possible risks. Park operators said they provide instructional videos and safety brochures, and have supervisors monitoring participants.

Trampoline parks aren't monitored by any state agency, said Peter Melton, spokesman for the California Department of Industrial Relations.

At the Torrance park where young Akory was showing off his basketball potential, Shannon Brown was leading the SkyRobics class, her ponytail bopping through a series of jumping jacks. Soon she had the four participants running across 24 trampolines, then doing push-ups and a dodge ball scrimmage.

"I've had kids as young as 8 years old and older people in their 50s and 60s," Brown said, adding that she tailors the classes to participants' skill level. "It's definitely a lot harder than it looks."

Law firm intern David Moussa, 21, of Torrance was among the participants. Moussa, who tore a knee ligament during a basketball game, said he enjoys the trampoline workouts because they impact his joints less than running.

"At first it was a little weird," Moussa said, as beads of perspiration formed on his forehead. "When I first did this I thought, 'I'm this big macho guy who plays basketball,'" he said, "but after the first couple of minutes I was done."

Deon Coates, 29, of Bellflower has taken his son Akory to the Torrance Sky Zone three times.

"The place is extremely clean and never understaffed; it really gives you a sense of safety," Coates said. "Plus, it's a perfect way to get the kids to sleep versus NyQuil."

adolfo.flores@latimes.com

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Lakers fire Mike Brown as coach

Mike Brown directs Steve Nash and Kobe Bryant. (Wally Skalij / Los Angeles Times / October 30, 2012)

By Mike Bresnahan

November 9, 2012, 10:10 a.m.

The Lakers have fired Mike Brown as coach after the team's 1-4 start, according to a person familiar with the situation but not authorized to speak publicly about it.

Brown was barely a month into his second season with the team, which struggled badly amid high expectations.

[Updated at 10:45 a.m.: Assistant coach Bernie Bickerstaff will coach tonight's game against Golden State but the Lakers will conduct a national search for a long term replacement. Candidates could include Mike D'Antoni, Jerry Sloan, Nate McMillan and Phil Jackson.]

PHOTOS: Lakers fire Mike Brown

It was believed to be the earliest firing of a coach in the team's history. Del Harris was relieved of his duties 12 games into the 1999 season.

The Lakers were 41-25 in Brown's first season, losing to Oklahoma City in the second round of the playoffs.

The team has had trouble picking up Brown's Princeton-based offense and has also lagged defensively.

ALSO:

Preview: Lakers vs. Warriors tonight

Lakers are in last place after loss to the Jazz

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‘NBA 2K13′ tops video games titles in October

NEW YORK (AP) — U.S. retail sales of new video game hardware, software and accessories fell 25 percent in October, marking the 11th straight month of declining sales for physical game products, according to a report from NPD Group.

Many gamers are waiting for big holiday releases such as Activision‘s “Call of Duty: Black Ops II.”

NPD said sales fell to $ 755.5 million from $ 1 billion a year earlier. Sales of video games themselves, excluding PC titles, fell 25 percent to $ 432.6 million. Sales of hardware such as Microsoft‘s Xbox 360 fell 37 percent to $ 187.3 million. Sales of accessories, meanwhile, grew 5 percent to $ 135.6 million.

Thursday’s study from NPD Group tracks sales of new physical products — about 50 percent of the total spending. Excluded are sales of used games and rentals as well as digital and social-network spending.

NPD also listed the top-selling games in October:

1. “NBA 2K13,” Take-Two Interactive Software Inc.

2. “Resident Evil 6,” Capcom USA

3. “Pokemon Black Version 2,” Nintendo Co.

4. “Dishonored,” Bethesda Softworks

5. “Pokemon White Version 2,” Nintendo Co.

6. “Madden NFL 13,” Electronic Arts Inc.

7. “FIFA Soccer 13,” Electronic Arts Inc.

8. “Medal of Honor: Warfighter,” Electronic Arts Inc.

9. “Borderlands 2,” Take-Two Interactive Software Inc.

10. “Skylander Giants,” Activision Blizzard Inc.

Gaming News Headlines – Yahoo! News

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Obama, Palin and Jobs join Bartlett's club

NEW YPRK (AP) — So much has changed since we last heard from "Bartlett's Familiar Quotations," a decade ago.

Barack Obama was a state legislator. Sarah Palin was mayor of Wasilla. Steve Jobs had just introduced a portable music player called the iPod.

And digital books were a relic from the dot-com bubble.

The 18th edition of the venerable reference work has just been released, the first for the electronic age and a chance to take in some of the new faces, events and catchphrases of the past 10 years. General editor Geoffrey O'Brien says he has expanded upon the trend set by his predecessor, Justin Kaplan, of incorporating popular culture into an anthology once known for classical citations. Shakespeare and the Bible still reign, but room also has been made for Madonna and Michael Moore, Justin Timberlake and Jon Stewart.

"I also added a great many quotes that originated in other languages. So I would say the new edition has a more international scope," says O'Brien, an author and critic and editor in chief of the Library of America, which publishes hardcover volumes of canonical American authors.

Little, Brown and Company hopes the new Bartlett's will appeal both as an old-fashioned coffee table hardcover, some 1,400 pages, and as an ultra-portable digital reference guide. Instead of releasing an e-book edition, the publisher has developed an app that does not simply replicate the printed book, but makes it ideal for digital devices and easy to share on Facebook or Twitter.

Dozens of employees spent months working on the app, according to Brian Singh, mobile analyst for Little, Brown's parent company, Hachette Book Group. Some 20,000 quotations were categorized so those looking for a quick quote — say a love poem for a wedding speech — could simply search the word "love." The app costs $3.95 and does not include any extra material, but it does have a digital feature, Quoto, which allows users to take a favorite citation, set it against a backdrop of choice and post it online.

For the hardcover, O'Brien said he removed some old poetry and forgotten phrases to make room for about 2,500 new quotes, including several from the Iraq War. Among them are President George W. Bush's call to "Bring 'em on" in response to possible uprisings from insurgents and his declaration that he was the "the decider." The Dixie Chicks' Natalie Maines is mentioned for her on-stage remark that she was "ashamed" Bush was from Texas, as is Moore's Academy Award acceptance speech when he criticized the war and called Bush a "fictitious president."

Seven Obama quotations are listed, from his campaign slogan "Yes, we can!" to his announcement that U.S. special forces had killed Osama bin Laden. Palin's entry includes the quip from her speech at the 2008 Republican convention that the difference between a hockey mom and a pit bull was "lipstick." Job's dying words, "Wow, oh wow," are among four citations for the late Apple CEO, including a 1987 comment that "It's more fun to be a pirate than to join the Navy."

Others in Bartlett's for the first time: Christopher Hitchens ("Seek out argument and disputation for their own sake"); David Foster Wallace ("Make no mistake: irony tyrannizes us"), Stewart (his nightly signoff, "Here it is ... your moment of Zen"), Timberlake (his apology for Janet Jackson's "wardrobe malfunction" during the 2004 Super Bowl halftime show).

Barlett's is home to polished aphorisms and unintentional history: Bill Clinton's "I did not have sex with that woman, Monica Lewinsky"; Oscar winner's Sally Field's cry that "You like me!"; Obama's comments at a private fundraiser that some rural residents "cling to guns or religion." Some quotes originate from tragedy: Rodney King's plea, "Can we all get along?", as Los Angeles burned during the 1992 riots; Flight 93 passenger Todd Beamer calling out "Let's roll" as he led an uprising against Sept. 11, 2011 hijackers.

The credentials for Bartlett's are admittedly arbitrary: Space concerns, individual tastes and the uncertain definition of the word "familiar" make the book an invaluable excuse for an argument.

Larry David is in, but not Aaron Sorkin; P.J. O'Rourke, not Maureen Dowd; Jerry Seinfeld and Steve Martin, not George Carlin or Richard Pryor. The many expressions coined on "Saturday Night Live," from "Talk amongst yourselves" to "Well, excuuuuuse me!" were not mentioned. Among novelists, Richard Powers is in, but not Jonathan Franzen; Colson Whitehead, not Michael Chabon.

"I am sure that twelve different well-informed people would come up with twelve different lists of people (and more importantly of specific quotations) left out, and I am sure some of these will be strong candidates for inclusion in the next edition," O'Brien said.

Among songwriting entries, excerpts appear from Lou Reed's lyrics for "All Tomorrow's Parties" and "Heroin," but not from the more famous "Walk On the Wild Side." The Beach Boys' "Carolina, No" gets a mention, but not such anthems as "Surfin' U.S.A." and "Good Vibrations." Kurt Cobain's entry omits "Smells Like Teen Spirit" in favor of "Stay Away" and "Serve the Servants."

For movies, two quotes are included from Robert Towne's "Chinatown" screenplay, but not the immortal closing line, "Forget it Jake, it's Chinatown." One of just two entries for Nora Ephron is "I'll have what she's having," the joke from "When Harry Met Sally ..." that is widely credited to Billy Crystal. Among the favorites left out: "Well, nobody's perfect," the kicker from "Some Like it Hot"; Arnold Schwarzenegger's "Terminator" catchphrase "I'll be back"; the courtroom explosion "You can't handle the truth!" from "A Few Good Men."

"Certain lines strike me as 'familiar for being familiar' — 'You can't handle the truth' being one of them, as I can see little originality or singularity in it," O'Brien said. "The price of compactness is a certain amount of arbitrary exclusion."

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Malaria Vaccine Candidate Produces Disappointing Results in Clinical Trial

The latest clinical trial of the world’s leading malaria vaccine candidate produced disappointing results on Friday. The infants it was given to had only about a third fewer infections than a control group.

But researchers said they wanted to press on, assuming they keep getting financial support, because the number of children who die of malaria is so great that even an inefficient vaccine can save thousands of lives.

Three shots of the vaccine, known as RTS, S or Mosquirix and produced by GlaxoSmithKline, gave babies fewer than 12 weeks old 31 percent protection against detectable malaria and 37 percent protection against severe malaria, according to an announcement by the company at a vaccines conference in Cape Town.

Last year, in a trial in children up to 17 months old, the same vaccine gave 55 percent protection against detectable malaria and 47 percent against severe malaria.

The new trial “is less than we’d hoped for,” Moncef Slaoui, Glaxo’s chairman of research and development said in a telephone interview. “But if a million babies were vaccinated, we would prevent 260,000 cases of malaria a year. This is a disease that kills 655,000 babies a year — 31 percent of that is a very large number.”

The company, which has already spent more than $300 million on the vaccine, wants to keep forging ahead, he said, “but it is not just our decision.”

It also depends on the PATH Malaria Vaccine Initiative, which has put more than $200 million of its Bill and Melinda Gates Foundation financing into the vaccine, and on the World Health Organization, which has helped talk seven African countries into allowing the vaccine to be tested on their children.

The Gates Foundation declined to say how much money it was ultimately prepared to spend on an imperfect vaccine; this set of trials is set to go into 2014.

“The efficacy came back lower than we had hoped, but developing a vaccine against a parasite is a very hard thing to do,” Bill Gates said in a prepared statement. “The trial is continuing, and we look forward to getting more data to help determine whether and how to deploy this vaccine.”

All the families in the trial were given insecticide-impregnated mosquito nets and encouraged to use them; 86 percent did, so the vaccine worked despite other anti-malaria measures.

RTS, S contains a protein found on the parasite’s surface that provokes an immune reaction. It was first identified decades ago by two New York University scientists, Ruth and Victor Nussenzweig. The vaccine was developed by Glaxo in Belgium and initially tested on American volunteers by the Walter Reed Army Institute of Research. When the Gates Foundation began focusing on global health in the early part of this century, it was one of the first projects the foundation adopted. Different ways to make the vaccine more effective, including adding different boosters and giving more shots, are being experimented with. Other vaccines using different ways to provoke an immune reaction exist, but none are as far along in clinical trials.

Like an H.I.V. vaccine, one against malaria has proved an elusive goal. The parasite morphs several times, exhibiting different surface proteins as it goes from mosquito saliva into blood and then into and out of the liver. Also, even the best natural “vaccine” — catching the disease itself — is not very effective. While one bout of measles immunizes a child for life, it usually takes several bouts of malaria to confer even partial immunity. Pregnancy can cause women to stop being immune, and immunity can fade out if someone moves away from a malarial area — presumably because they no longer get “boosters” from repeated mosquito bites.

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Liberty and Cherokee SUVs recalled to fix air bag problem

By Jerry Hirsch

November 9, 2012, 8:35 a.m.

Chrysler Group is recalling about 750,000 Jeep sport utility vehicles in the U.S. because the air bags can inflate without warning.

The recall includes model year 2002 and 2003 Jeep Liberty vehicles and 2002 through 2004 Jeep Grand Cherokees.

The recall includes an additional 170,000 of the vehicles globally.

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Chrysler said a component in the air bag control module can fail and cause the front air bags, side curtain air bags and seatbelt pretensioners to deploy while the vehicle is being operated.

That’s happened more than 200 times, causing 81 injuries but no reported crashes, according to the National Highway Traffic Safety Administration. In most cases, the air bags deploy only partially rather than with the full force that occurs when they are triggered by a crash.

A NHTSA investigation found that the inadvertent air bag deployment is caused by an electrical problem.

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Follow me on Twitter (@LATimesJerry), Facebook and Google+.

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Gabrielle Giffords expected to attend Jared Loughner sentencing

Victims in the Tucson shooting rampage will get a chance to confront gunman Jared Lee Loughner, who will be  sentenced Thursday for killing six and wounding 13 people, including then-Rep. Gabrielle Giffords.

Giffords and her retired astronaut husband Mark Kelly are expected to be in court and make a statement before Loughner is sentenced by U.S. District Court Judge Larry A. Burns in Tucson. Other victims are also expected to appear.

Giffords was making a routine political appearance mid-morning on Jan. 8, 2011 at a supermarket parking lot in her Tucson district when Loughner opened fire, shooting her in the head. Passers-by rushed to help Giffords and wrestled Loughner to the ground. Before Loughner was subdued, he fired 31 more shots.

TIMELINE: Deadliest mass shootings in the U.S.

The nation then waited as doctors worked to save Giffords’ life in what has been described as a miraculous recovery. She then turned to her long-term and inspirational rehabilitation. Her first visit to Congress before stepping down from office led to a prolonged ovation from her colleagues.

The facts in the case were never in doubt. Loughner was the only suspect and the question focused on whether he would avoid the death penalty because of his mental health. After the shooting, Loughner was diagnosed with schizophrenia and underwent forcible psychotropic drug treatments.

Burns ruled that Loughner, now 24, was able to understand the charges against him, which eventually paved the way for a plea bargain designed to ensure that he would spend the rest of his life in prison without possibility of parole.

Three months ago, Loughner pleaded guilty to 19 federal charges. The agreement includes the dismissal of 30 other charges and a sentence of seven consecutive life terms, followed by 140 years in prison.

Giffords and some of the other victims said at the time that they welcomed the agreement because it meant that they could avoid a long and emotionally challenging court process that would have demanded they relive the events of that day.

Christina Pietz, the court-appointed psychologist who treated Loughner, had warned that although he was competent to plead guilty, he remained severely mentally ill and that he could deteriorate if forced to stand trial. Loughner, who has been in a prison medical facility in Springfield, Mo., for more than a year, is expected to serve his sentence in prison wards for the mentally ill.

Other victims are expected to make comments. Rep. Ron Barber, a former top aide to Giffords who replaced his boss in Congress, is expected to issue a statement. Barber is still awaiting word on whether he was re-elected to the seat on Tuesday.

Thursday’s proceedings end the federal case against Loughner. Pima County officials are still deciding whether to bring state charges.

Killed in the attack were:  John Roll, 63, presiding U.S. District Court judge for Arizona; Gabe Zimmerman, 30, one of Giffords' staffers; Christina-Taylor Green, a 9-year-old attending Giffords' event with an adult neighbor;  Dorwan Stoddard, 76; Dorothy Morris, 76; and Phyllis Schneck, 79, three retirees at the event.

In addition to Giffords and Barber, the wounded were: Mavy Stoddard (Dorwan's wife); George Morris (Dorothy's husband); Susan Hileman (Christina-Taylor's neighbor); Pam Simon, another Giffords staffer; and event attendees Bill Badger, Kenneth Dorushka, Eric Fuller, Randy Gardner, Mary Reed, James Tucker and Kenneth Veeder.

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Exclusive: Google Ventures beefs up fund size to $300 million a year

SAN FRANCISCO (Reuters) - Google will increase the cash it allocates to its venture-capital arm to up to $300 million a year from $200 million, catapulting Google Ventures into the top echelon of corporate venture-capital funds.

Access to that sizeable checkbook means Google Ventures will be able to invest in more later-stage financing rounds, which tend to be in the tens of millions of dollars or more per investor.

It puts the firm on the same footing as more established corporate venture funds such as Intel's Intel Capital, which typically invests $300-$500 million a year.

"It puts a lot more wood behind the arrow if we need it," said Bill Maris, managing partner of Google Ventures.

Part of the rationale behind the increase is that Google Ventures is a relatively young firm, founded in 2009. Some of the companies it backed two or three years ago are now at later stages, potentially requiring larger cash infusions to grow further.

Google Ventures has taken an eclectic approach, investing in a broad spectrum of companies ranging from medicine to clean power to coupon companies.

Every year, it typically funds 40-50 "seed-stage" deals where it invests $250,000 or less in a company, and perhaps around 15 deals where it invests up to $10 million, Maris said. It aims to complete one or two deals annually in the $20-$50 million range, Maris said.

LACKING SUPERSTARS

Some of its investments include Nest, a smart-thermostat company; Foundation Medicine, which applies genomic analysis to cancer care; Relay Rides, a carsharing service; and smart-grid company Silver Spring Networks. Last year, its portfolio company HomeAway raised $216 million in an initial public offering.

Still, Google Ventures lacks superstar companies such as microblogging service Twitter or online bulletin-board company Pinterest. The firm's recent hiring of high-profile entrepreneur Kevin Rose as a partner could help attract higher-profile deals.

Soon it could have even more cash to play around with. "Larry has repeatedly asked me: 'What do you think you could do with a billion a year?'" said Maris, referring to Google chief executive Larry Page.

(Editing by Muralikumar Anantharaman)

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Man pleads no contest in 'Bling Ring' case

LOS ANGELES (AP) — A man who had been accused of burglarizing Paris Hilton's home pleaded no contest on Thursday to receiving jewelry stolen from the house during a rash of break-ins by a group dubbed the "Bling Ring."

Roy Lopez Jr. was then sentenced to serve three years of supervised probation.

Lopez, 30, was initially charged with felony residential burglary and conspiring with other members of the ring that targeted the swank, Hollywood Hills homes of stars such as Hilton, Lindsay Lohan, Orlando Bloom and others.

Hilton's home was burglarized in December 2008, and police were able to return some of her property.

The burglary charge and other counts against Lopez were dropped. Deputy District Attorney Christine Kee said Hilton has opted not to receive restitution in the case.

Much of the estimated $3 million in high-end jewelry, clothes and art that was taken from the celebrities has never been recovered.

"We're pleased that the district attorney was able to work with us on this case and allow Roy to get his life back on track," defense attorney David Diamond said after the hearing.

Evidence in the case supported his contention that Lopez had never been in Hilton's residence, Diamond said.

Several other defendants, including the alleged ringleaders, have taken plea deals to end their cases. The remaining defendant, Courtney Leigh Ames, returns to court on Dec. 14.

Diana Tamayo, who pleaded no contest to burglarizing Lohan's home, might still be required to pay restitution in the case. Lohan has indicated she may seek restitution against Tamayo, but the actress was not available to be in court on Thursday, Kee said.

The case hit a snag recently after it was revealed that the lead police investigator was paid to consult and appear in an upcoming Sofia Coppola film based on the case.

Los Angeles Police Officer Brett Goodkin failed to disclose the work to his superiors and prosecutors ahead of time.

Superior Court Judge Larry Paul Fidler has called Goodkin's actions "stupid and a gift to defense attorneys," but not enough to warrant dismissal of any charges.

Fidler referenced the issue by telling Lopez, "You got a break because of what's happened in this case."

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Anthony McCartney can be reached at http://twitter.com/mccartneyAP

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Well: The Presidential Health Quiz

Whether it’s George Washington’s teeth or Bill Clinton’s former hamburger habit, Americans have always been fascinated by the health of the president and presidential candidates.

With help from the Web site DoctorZebra, which has compiled an exhaustive list of the medical history of American presidents, we’ve created an Election Day quiz to test your knowledge of presidential fitness and health.

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Amazon.com opens online wine marketplace, partners with wineries

As if shopping on Amazon.com needed to get any more dangerous: The online retailer will now start selling wine in a dedicated section on its site, just in time for the holidays.

Visitors to Amazon Wine will have access to more than 1,000 wines from wineries nationwide. Bottle prices range from less than $10 to more than $100, plus shipping costs of $9.99 for up to six bottles.

Amazon will serve as a sort of middle man and discovery center, partnering with wineries that provide the wine and use the online marketplace to raise awareness for their brands and make sales.

The wineries will provide tasting notes, recommended food pairings, alcohol content data and other information to be posted on the site. Customers can fine-tune their wine searches by filtering results for winery location, professional ratings and more.

“It is rare to have detailed information and opinions located all in one place,” Tom Hedges of Hedges Family Estate in Washington said in a statement. “What Amazon has done with their new wine store is take the experience of hundreds of tasting rooms and put them online.”

For now, wines will be shipped only to a dozen states, including California, as well as to Washington, D.C. Each winery operates under an distinct set of permits, which determines the states to which it can ship.

And underage drinkers can forget about using the service for an illegal binge. Amazon Wine requires both buyer and recipient to be over age 21 and will deliver only to adults, not to P.O. boxes or Amazon Lockers.

Wine has been available online for years through purveyors such as Wine.com, Winex.com and more.

This week, as if preparing to compete with Amazon Wine, Wine.com announced the similar Wine.com Marketplace after a soft launch earlier this year.

The wine retailer, currently the largest of its kind online with more than 2.5 million shipments a year, will handle all marketing, customer service, sales and delivery for participating wines.  

Most of the wines come from wineries with limited distribution ability who through Wine.com Marketplace will now have access to consumers in 20 states. Wine.com has traditionally bought its stock from wholesalers.

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